Neural Progenitor Cell Polarity and Cortical Development
نویسندگان
چکیده
منابع مشابه
Neural Progenitor Cell Polarity and Cortical Development
Neurons populating the cerebral cortex are generated during embryonic development from neural stem and progenitor cells in a process called neurogenesis. Neural stem and progenitor cells are classified into several classes based on the different location of mitosis (apical or basal) and polarity features (bipolar, monopolar and non-polar). The polarized architecture of stem cells is linked to t...
متن کاملMicrotubule-induced cortical cell polarity.
Most cells are polarized. Embryonic and stem cells can use their polarity to generate cell diversity by asymmetric cell division, whereas differentiated cells use their polarity to execute specific functions. For example, fibroblasts form an actin-rich leading edge required for cell migration, neurons form distinctive axonal and dendritic compartments important for directional signaling, and ep...
متن کاملMitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development.
Although high amounts of reactive oxygen species (ROS) can damage cells, ROS can also play roles as second messengers, regulating diverse cellular processes. Here, we report that embryonic mouse cerebral cortical neural progenitor cells (NPCs) exhibit intermittent spontaneous bursts of mitochondrial superoxide (SO) generation (mitochondrial SO flashes) that require transient opening of membrane...
متن کاملPredicting Neural Progenitor Cell Networks
Predicting neuronal networks from calcium fluorescence data is extremely difficult due to the nature of the data collection. Current methods to overcome this difficulty, while powerful, are somewhat arbitrary, presenting new difficulties in later analysis. Specifically, current ad-hoc methods often make arbitrary distinctions between connected and unconnected neurons. In this project, I attempt...
متن کاملApicobasal polarity and cell proliferation during development.
Cell polarization and cell division are two fundamental cellular processes. The mechanisms that establish and maintain cell polarity and the mechanisms by which cells progress through the cell cycle are now fairly well understood following decades of experimental work. There is also increasing evidence that the polarization state of a cell affects its proliferative properties. The challenge now...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Cellular Neuroscience
سال: 2017
ISSN: 1662-5102
DOI: 10.3389/fncel.2017.00384